Following are References to Papers Relating to the Efficacy of Colostrum*:
Allergies | Alzsheimers | Anti-Aging | Asthma | Anti-Inflammatory | Anti-Oxidant Properties | Athletic Performance | Bacterial Infections | Cancer | Cytokines |Diabetes | General Information | Growth Factors | Heart Disease | Immune Factors | Immune System | Infant Health | Intestinal Permeability | Lactoferrin | Leaky Gut Syndrome | Other | Other auto-immune disorders | Multiple Schlerosis (Auto-Immune Condition) | Rheumatoid Arthritis | Sjogren's Syndrome | Skin Health | Supplement for Human Use| HIV/AIDS | Viral Infections (Acute) | Wound Healing
Growth Factors
Growth Factors
Akita EM, Li-Chan EC. Isolation of bovine immunoglobulin G subclasses from milk, colostrum, and whey using immobilized egg yolk antibodies. J Dairy Sci 1998; 81: 54-63.
George-Nascimento, C., Lowenson, Jonathan, Borissenko, M., Calderon, A., Medina-Selby, A., Kuo, J., Clarke, S., Randolph, A. Replacement of a Labile Aspartyl Residue Increases the Stability of Human Epidermal Growth Factor. Biochemistry 29 No. 41(1990) 9584 - 9591.
Antonio J. (1998) Can bovine colostrum enhance levels of IGF-1? Muscle and Fitness Magazine, 1998.
Ballard F, Wallace J, Francis G, Read L, Tomas F. (1996) Des (1-3) IGF-I: a truncated form of insulin-like growth factor-I. International Journal of Cellular Biology. 28:1085-1087.
Bergerot, I, et al. Effects of insulin like growth factor-1 and insulin on effector T cells generating autoimmune diabetes. Diabetes & Metabolism 22(4):235-239 (1996). The development of autoimmune diabetes in experimental mice was significantly reduced in those receiving IGF-1 as compared to insulin.
Bhora F, Dunkin B, Batzri S, et al. (1995) Effect of growth factors on cell proliferation and epithelialization in human skin. Journal of Surgery Res. 59:236-244.
Bhora, Y, et al. Effect of growth factors on cell proliferation and epithelialization in human skin. Journal of Surgical Research 59(2):236-244 (1995). Fibroblast growth factor (FGF), IGF-1 and epithelial growth factor (EGF) are important factors in healing skin wounds. EGF in particular is capable of initiating epithelial growth.
Bricker D. (1991) Colostrum: Implications for accelerated recovery in damaged muscle and cartilage, prevention of some pathogenic disease. The American Chiropractor.
Burrin D, Davis T, Ebner S, Schoknecht P, Fiorotto M, Reeds P. (1997) Colostrum enhances the nutritional stimulation of vital organ protein synthesis in neonatal pigs. American Society for Nutritional Sciences.127(7):1284-9.
Burrin DG, Shulman RJ, Reeds PJ, Davis TA, Gravitt KR. (1992) Porcine colostrum and milk stimulate visceral organ and skeletal muscle protein synthesis in neonatal piglets. Journal of Nutrition. 122:1205-1213.
Cass TL. Insulin-like growth factor-1 (IGF-1, Somatomedin C) blood levels are not associated with prostate specific antigen (PSA) levels or prostate cancer: A study of 749 patients. Medical College of Wisconsin, Milwaukee, WI.
Demarco C. (1998) Anti-aging breakthrough: Homeopathic growth factors. Let's Live.
Dohm, GL, et al. IGF-I-stimulated glucose transport in human skeletal muscle and IGF-I resistance in obesity and NIDDM. Diabetes 39(9):1028-1032 (1990). IGF-1 stimulates glucose transport by IGF-1 receptors in skeletal muscle, thus alleviating the hyperglycemia observed in non-insulin-dependent diabetes mellitus (NIDDM). Significantly, muscle from obese patients was resistant to this effect.
Donovan, SM, Hartke, JL, Monaco, MH, Wheeler, MB. (2004) Insulin-like Growth Factor-I and Piglet Intestinal Development. Journal of Dairy Science 87(E Suppl.):E46-54. Piglets suckling from IGF-1 transgenic sows (i.e. sows that have been transgenically altered to overexpress IGF-1 in their milk) showed increased villus growth and disaccharidase activity, indicating improved intestinal health.
Francis G, Read L, Ballard J, et al. (1986) Purification and partial sequence analysis of insulin-like growth factor-1 from bovine colostrum. Journal of Biochemistry. 233:207-213.
Francis G, Upton F, Ballard J, McNeil K, Wallace J. (1988) Insulin-like growth factors 1 and 2 in bovine colostrum. Journal of Biochemistry. 251:95-103.
Fryburg D. (1995) Insulin and insulin-like growth factor 1 enhance human skeletal muscle protein anabolism during Hyperaminoacidemia by different mechanisms. Journal of Clinical Investigations. 96:1722-1729.
Ginjala V, Pakkanen R. (1998) Determination of transforming growth factor-B1 (TGF-B1) and insulin-like growth factor 1 (IGF-1) in bovine colostrum samples. Journal of Immunoassay. 19:195-207.
Handsell KL, Baumrucker CR, Kensinger RS. (1993) Effects of elevated blood insulin-like growth factor-I (IGF-I) concentration upon IGF-I in bovine mammary secretions during the colostrum phase. Journal of Endocrinology. 137:223-230.
Hasdai, D, et al. Insulin and insulin-like growth factor I cause coronary vasorelaxation in vitro. Hypertension 32:228-234 (1998). IGF-1 and insulin affect vasorelaxation in coronary arteries, possibly by activating potassium channels.
Hyde, C, et al. Insulin-like Growth Factors (IGF) and IGF-Binding Proteins Bound to Vitronectin Enhance Keratinocyte Protein Synthesis and Migration. Journal of Investigative Dermatology 122(5):1198-1206 (2004). IGF-II binds directly to vitronectin, a component of the extracellular skin matrix, to enhance protein synthesis and migration by skin cells in wound healing and skin regeneration.
Juskevich J. (1990) Bovine Growth Hormone: Human Food Safety Evaluation. Science. 249:875-883.
Kirkpatrick CH. (1993) Structural nature and function of transfer factors. Annals New York Academy of Sciences. 685:362-8.
Marcotty C, Frankenne F, Van Beeumen J, Maghuin-Rogister G, Hennen G. (1991). Insulin-like growth I (IGF-I) from cow colostrum: Purification and characterization. Growth Regulation. 1(2):56-61.
Marquardt H, Lioubin MN, Ikeda T. (1987) Complete amino acid sequence of human transforming growth factor type beta 2. Journal of Biological Chemistry. 262:12127-12131.
Mero A, Kahkonen J, Nykanen T, Parviainen T, Jokinen I, Takala T, Nikula T, Rasi S, Leppaluoto J. Appl Physiol. 2002 Aug;93(2):732-9. Related Articles, IGF-I, IgA, and IgG responses to bovine colostrum supplementation during training. Journal of Applied Physiology, Vol. 83, No. 4, pp. 1144-1151, October 1997
Miers W, Barrett E. (1998) The role of insulin and other hormones in the regulation of amino acid and protein metabolism in humans. Journal of Basic and Clinical Physiology and Pharmacology. 9(2-4):235-53.
Noda K, Umeda M, Ono T. (1984) Transforming growth factor activity in human colostrum. Gann. 75:109-12.
Nowak J, Olszewski J, Kozal E. (1994) Insulin and sugar concentration changes in mammary secretion in sheep during the periparturient period. Reprod. Nutritional Development. 34:3-8.
Nowak J. (1990) Insulin and glucose concentration changes in newborn piglets after suckling the colostrum from insulin administered sows. Acta Physiol. 41(7):155-62.
Oda S, Satoh H, Sugawara T, et al. (1989) Insulin-like growth factor-I, GH, insulin and glucagon concentrations in bovine colostrum and in plasma of dairy cows and neonatal calves around parturition. Comp. Biochemical Physiology. 94A:805-808.
Oda, S., et al., Insulin-like growth factor-l (IGF-1), growth hormone (GH), insulin and glucagon concentrations in bovine colostrum and in plasma of dairy cows and neonatal calves around parturition. Comp. Biochem. Physiol. 1989. 94A(4): p. 805-808.
Oz, HS, Ray, M, Chen, TS, McClain, CJ. (2004) Efficacy of a transforming growth factor beta 2 containing nutritional support formula in a murine model of inflammatory bowel disease. Journal of the American College of Nutrition 23(3):220-6. Mice with an experimentally-induced inflammatory bowel disease fed a diet rich in transforming growth factor beta-2 (TGF-ß2) gained more weight, did not develop diarrhea or prolapse, had lower pathological scores and lower serum amyloid (SAA). This study supports the use of TGF-ß2 diets in the treatment of Crohn’s disease.
Pakkanen R, Aalto J. (1997) Review paper: Growth factors and antimicrobial factors of bovine colostrum. International Dairy Journal. 7:285-297.
Pakkanen R. (1998) Determination of transforming growth factor-fl2 (TGF-fl2) in bovine colostrum samples. Journal of Immunoassay. 19:23-37.
Rosenthal S, Brown E, Brunetti A, Goldfine I. (1991) Fibroblast growth factor inhibits insulin-like growth factor-II (IGF-II) gene expression and increases IGF-I receptor abundance in BC3H-1 muscle cells. Molecular Endocinology. 5:678-684.
Rudman, D.; et al. Effects of Human Growth Hormone in Men over 60 Years Old. N. Eng. J. Med. 323:1-6, 1990.
Rudman, D, et al. Effects of human growth hormone in men over 60 years old. New England Journal of Medicine 323(1):1-6 (1990). The decline in activity of the growth hormone-IGF-1 system may be related to the loss of lean muscle mass and increase in fat mass with aging. Administration of growth hormone to men over 60 years of age resulted in increased IGF-1 levels in the blood similar to that found in much younger men, increase lean body mass, decreased fat mass and an increase in skin thickness.
Russell, JW, Feldman, EL. Insulin-like growth factor-I prevents apoptosis in sympathetic neurons exposed to high glucose. Hormone and Metabolic Research 31(2-3):90-96 (1999). Using an experimental in vitro rat superior cervical ganglion model of diabetic neuropathy, high levels of glucose, such as are found in uncontrolled diabetes, inhibits neurite (cell processes growing from nerve cells in cultures) growth, reduction in neurite size, beading of neurites, neurite retraction and apoptosis (cell death) in neurons. This is reversed by IGF-1 which exhibits a neuroprotective effect on these neurons. This suggests that IGF-1 may be of use in preventing diabetic neuropathy in vivo.
Sara VR, Hall K. (1990) Insulin-like growth factors and their binding proteins. Physiological Reviews. 70:591-606.
Shimizu M, Webster C, Morgan DO, Blau HM, Roth RA. (1986) Insulin and insulin-like growth factor receptors and responses in cultured human muscle cells. American Journal of Physiology. 251:E611-5.
Shing Y, Klagsbrun M. (1987) Purification and characterization of a bovine colostrum-derived growth factor. Molecular Endocrinology. 1:335-338.
Skottner A, Arrhenius-Nyberg V, Kanje M, Fryklund L. (1990) Anabolic and tissue repair functions of recombinant insulin-like growth factor I. Acta Pediatric Scand. 367:63-66.
Sporn M, Roberts A, Shull J, Smith J, Ward J. (1983) Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo. Science. 219(4590):1329-31.
Shomali M, Wolfsthal S. (1997) The use of anti-aging hormones. Maryland Medical Journal. 46:181-186.
Tokuyama H, Tokuyama Y, Migita S. (1990) Isolation of two new proteins from bovine colostrum which stimulates epidermal growth factor-dependent colony formation of NRK-49F cells. Growth Factors. 3(2): 105-14.
Tokuyama, H. and Tokuyama, Y. (1989) Bovine colostric transforming growth facto-fI-like peptide that induces growth inhibition and changes in morphology of human osteogenic sarcoma cells (MG-63). Cell Biology International Reports. 13:251-258.
Tokuyama Y. (1993) Purification and identification of TGF-B2-related growth factor from bovine colostrum. Journal of Dairy Research. 60:99-109.
Tollefsen S, Lajara R, McCusker R, Clemmons D, Rotwein P. (1989) Insulin-like growth factors (IGF) in muscle development. Journal of Biological Chemistry. 264(23):13810-7.
Tomas F, Knowles S, Owens P, et al. (1991) Increased weight gain, nitrogen retention and muscle protein synthesis following treatment of diabetic rats with insulin-like growth factor (IGF)-I and des(1-3)IGF-I. Biochem J. 276 (Pt 2):547-54.
Ullman M, Ullman A, Sommerland H, Skottner A, Oldfors A. (1990) Effects of growth hormone on muscle regeneration and IGF-I concentration in old rats. Acta Physiological Scand. 140:521-525.
Watson DL, Francis GL, Ballard FJ. (1992) Factors in ruminant colostrum that influence cell growth and murine IgE antibody responses. Journal of Dairy Research. 59:369-380.
Tavakkol, A, et al. Expression of growth hormone receptor, insulin-like growth factor 1 (IGF-1) and IGF-1 receptor mRNA and proteins in human skin. Journal of Investigative Dermatology 99(3):343-349 (1992). Receptors for growth hormone and IGF-1 were isolated from human skin, indicating that skin cells may have the ability to react directly to growth hormone stimulation.
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Heart Disease
Heart Disease
FitzGerald, RJ, Murray, BA, Walsh, DJ. (2004) Hypotensive peptides from milk proteins. Journal of Nutrition 134(4):980S-988S. Casokinins and lactokinins from milk and colostrum are potent ACE inhibitory peptides. Several human studies have associated these milk protein-derived peptides with statistically significant hypotensive effects (i.e., lower systolic and diastolic pressures).
Gilliland, S. E.; Nelson, C. R.; Maxwell, C. "Assimilation of Cholesterol by Lactobacillus Acidophilus" Appld and Envir Microbiol. 49:377-81, 1985.
Lange; Schreiner. "Immune Mechanisms of Cardiac Disease" New England Journal of Medicine. 330:1129, 1994.
Robert, L.; et al. "The Effect of Procyanidolic Oligomers on Vascular Permeability. A Study Using Quantitative Morphology," Pathol Biol. 38:608-616, 1990.
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Immune Factors
Immune Factors
Bocci V, Von Bremen K, Corradeschi F, Luzzi E, Paulesu L. (1991) What is the role of cytokines in human colostrum? Journal of Biological Regulators and Homeostatic Agents. 3:121-124.
Boesman-Finkelsein M, Walton NE, Finkelstein RA. (1989) Bovine lactogenic immunity against cholera toxin-related enterotoxins and Vibrio cholerae outer membranes. Infection and Immunity. 57:1227-1234.
Boesman-Finkelstein M. and Finkelstein R. (1989) Passive oral immunization of children. Lancet. 2(8675):1336.
Bogstedt AK, Johansen K, Hatta H, et al. (1996) Passive immunity against diarrhea. Acta Paediatr. 85:125-128.
Davidson G, Whyte P, Daniels E, et al. (1989) Passive immunization of children with bovine colostrum containing antibodies to human rotavirus. Lancet. 2(8665):709-12.
Dichtelmuller W, Lissner R. (1990) Antibodies from colostrum in oral immunotherapy. Journal of Clinical Biochemistry. 28:19-23.
Ebina T, Umezu K, Ohyama S, et al. (1983) Prevention of rotavirus infection by cow colostrum containing antibody against human rotavirus. Lancet. 2(8357):1029-30.
Francis, G. L., et al., Purification and partial sequence analysis of insulin-like growth factor-l (IGF-1) from bovine colostrum. Biochem. J. 1986. 233: p.207-213.
Francis, G. L., et al., Insulin-like growth factors-l (IGF-1) and 2 (IGF-2) in bovine colostrum. Biochem. J. 1988. 251:p. 95-103.
Hanson LA, Ahlstedt S, Andersson B, et al. (1983) Mucosal Immunity. Annals New York Academy of Sciences. 83:1-20.
Hilpert H, Brussow H, Mietens C, Sidoti J, Lerner L, Werchau H. (1987) Use of bovine milk concentrate containing antibody to rotavirus to treat rotavirus gastroenteritis in infants. Journal of Infectious Diseases. 156:158-166.
Hirmo S, et al. (1998) Characterization of Helicobacter pylori interactions with sialylglycoconjugates using a resonant mirror biosensor. Analytical Biochemistry. 257:63-6.
Hoffman M. (1992) Transferred immune cells may help fight viral infection. Immunology. 257(5067):166.
Honorio-Franca A, Carvalho M, Isaac L, Trabulsi l, Carneiro-Sampaio M. (1997) Colostral mononuclear phagocytes are able to kill enteropathogenic Escherichia coli opsonized with colostral IgA. Scandavian Journal of Immunology. 46:59-66.
Huppertz H, Rutkowski S, Busch D, Eisebit R, Lissner R, Karch H. (1999). Bovine colostrum ameliorates diarrhea in infection with diarrheagenic Escherichia coli, shiga toxin producing E.coli, and E-coli expressing intimin and hemolysin. Journal of Pediatric Gastroenterology and Nutrition. 29:452-456 (1999).
Janusz M, Lisowski J. (1993) Proline-rich polypeptide (PRP) - an immunomodulatory peptide from ovine colostrum. Archivum Immunologiae et Therapiae Experimentalis. 41:275-279.
Jochims K, Kaup F, Drommer W, Pickel M. (1994) An immunoelectron microscopic investigation of colostral IgG absorption across the intestine of new-born calves. Research in Veterinary Science. 57:75-80.
Kelly CP, et al. (1996) Anti-Clostridium difficile bovine immunoglobulin concentrate inhibits cytotoxicity and enterotixicity of C. difficile toxins. Antimicrobial Agents and Chemotherapy. 40:373-379.
Kelly G. (1999) Larch arabinogalactan: Clinical relevance of a novel immune-enhancing polysaccharide. Alternative Medicine Review. 4(2):96-103.
Khazenson L, Gennad'eva T, Roshchin V, Krasheniuk A, Semenova N. (1980) Activity of bovine colostral IgG in the human digestive tract. ZH Mikrobiol Epidemiol Immunobiol. 9:101-106.
Kohl S, Malloy M, Pickering L, Morriss F, Adcock E, Walters D. (1978) Human colostral cytotoxicity: I. Antibody-dependent cellular cytotoxicity against herpes simplex viral-infected cells mediated by colostral cells. Journal of Clinical Laboratory Immunology. 1:221-224 .
Korthonen H, Suvaoja EL, Ahola-Luttilia H, et al. (1995) Bactericidal effect of bovine normal and immune serum, colostrum and milk against Helicobactor pylori. Journal of Applied Bacteriology. 78:655-662.
Lawton JW, Shortridge KF, Wong RL, Ng MH. (1979) Interferon synthesis by human colostral leucocytes. Archives of Disease in Childhood. 54:127-130.
LeFranc-Millot C, Vercaigne-Marko D, Wal J. -M, et al. (1996) Comparison of the IgE titers to bovine colostral G immunoglobulins and the F(ab')2 fragments in sera of patients allergic to milk. Int Arch Allergy Immunol. 110:156-162.
Lissner R, Thurmann P, Merz G, Karch, H. (1998) H. Antibody reactivity and fecal recovery of bovine immunoglobulins following oral administration of a colostrum concentrate from cows to healthy volunteers. International Journal of Clinical Pharmacology and Therapeutics 36:239-245.
McConnell, M. A., Buchan, G. A. A., Borissenko, M. V., Brooks, H. J. L. (2001). A Comparison of IgG and IgG1 Activity in an Early Milk Concentrate from Non-Immunised Cows and a Milk from Hyperimmunised Animals. Food Research International 34 (2001) 255 - 261.
Michalek SM, McGhee JR, Babb JL. (1978) Effective immunity to dental caries: dose-dependent studies of secretory immunity by oral administration of Streptococcus mutans to rats. Infection and Immunity. 19:217-224.
Moro I, Abo T, Crago SS, Komiyama K, Mestecky J. (1985) Natural Killer Cells in Human Colostrum. Cellular Immunology. 93:467-474.
Ogra P, Losonsky G, Fishaut M. (1983) Colostrum-derived immunity and maternal-neonatal interaction. New York Academy of Science 409:82-95.
Ogra SS, Ogra PL. (1978) Immunologic aspects of human colostrum and milk. The Journal of Pediatrics. 92:546-549.
Parodi PW. (1996) Milk fat components: possible chemopreventive agents for cancer and other diseases. The Australian Journal of Dairy Technology. 51:24-32.
Petschow B, Talbott R. (1994). Reduction in virus-neutralizing activity of a bovine colostrum immunglobulin concentrate by gastic acid and digestive enzymes. Journal of Pediatric Gastroenterology and Nutrition. 19:228-235.
Plettenberg A, Stoehr A, Stellbrink J, Albreacht H, Meigel W. (1993) A preparation from bovine colostrum in the treatment of HIV-positive patients with chronic diarrhea. Clinical Investigator. 71:42-45.
Pincus C, Nussenweig V. (1971) Regulation of the Immune Response: Suppressive and enhancing effects of passively administered antibody. Journal of Experimental Medicine. 133:987-1003.
Pironi L, Miglioli M, Ruggeri E, et al. (1990) Relationship between intestinal permeability to EDTA and inflammatory activity in asymptomatic patients with Crohn's disease. Digestive Diseases and Sciences. 35(5):582-8.
Quigley JD, Martin KR, Dowlen HH, Wallis LB, Lamar K. (1994) Immunoglobulin concentration, specific gravity, and nitrogen fractions of colostrum from Jersey cattle. Journal of Dairy Science. 77:264-269.
Rautiainen E. (1998) The prevalence of Mycoplasma hyopneumoniae in pig herds in western Finland based on the demonstration of antibodies in colostrum by ELISA. Acta Vet Scand. 39:325-330.
Ritchie D, Becker E. (1994) Update on the management of intestinal cryptosporidiosis in AIDS. The Annals of Pharmacotherapy. 28:767-778.
Robert Service. (1994) Triggering the First Line of Defense. Research News. 265.
Saif L, Smith K. (1985) Enteric viral infections of calves and passive immunity. Journal of Dairy Science. 68:206-228.
Sandholm M, Honkanen-Buzalski T. (1979) Colostral trypsin-inhibitor capacity in different animal species. Acta Vett. Scand. 20:469-476.
Sarker S, Casswall T, Mahalanabis M, et al. (1998) Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum. Pediatric Journal of Infectious Disease. 17:1149-54.
Savilahti E, Tainio VM, Salmenpera L, Arjomaa P, Kallio M, Perheentupa J, Siimes MA. (1991) Low colostral IgA associated with cow's milk allergy. Acta Pediatr Scan. 80:1207-1213.
Selo I, Clement G, Bernard H, et al. (1999) Allergy to bovine B-lactoglobulin: specificity of human IgE to tryptic peptides. Clinical and Experimental Allergy. 29:1055-1063.
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Siber G. (1992) Immune globulin to prevent nosocomial infection. New England Journal of Medicine. 327(4):269-71.
Stephen W, Dichtelmuller H, Lissner R. (1990) Antibodies from colostrum in oral immunotherapy. Journal of Chemical Clinical Biochemistry. 28:19-23.
Staroscik K, Janusz M, Zimecki M, Wieczorek Z, Lisowski J. (1983) Immunologically active nonapeptide fragment of a proline-rich polypeptide from ovine colostrum: amino acid sequence and immunoregulatory properties. Molecular Immunology. 12:1277-1282.
Swarbrick ET. (1992) The handling of ingested antigens. Am J Trop Med Hyg. 47(3):276-83.
Tacket CO, Binion SB, Bostwick E, Losonsky G, Roy MJ, Edelman R. Efficacy of bovine milk immunoglobulin concentrate in preventing illness after Shigella flexneri challenge. Am. J. Trop. Med. Hyg. 47:276-283 (1992).
Takahashi, T. and et al. (1998) Effects of Orally Ingested Bifidobacterium longum on the Mucosal IgA response of Mice to Dietary Antigens. Biosci Biotechnol Biochem. 62(1):10-5.
Tejada-Simon M, Lee J, Ustunol Z, Pestka J. (1999) Ingestion of yoghurt containing lactobacillus acidophilus and bifidobacterium to potentiate immunoglobulin A responses to cholera toxin in mice. Journal of Dairy Science. 82:649-660.
Tyler J, Stevens B, Hostetler D, Holle J, Denbigh J. (1999) Colostral immunoglobulin concentrations in holstein and guernsey cows. American Journal of Veterinary Research. 60(9):1136-9
Tzipori S, Roberton D, Chapman C. (1986) Remission of diarrhea due to cryptosporidiosis in an immunodeficient child treated with hyperimmune bovine colostrum. British Medical Journal. 293(6557):1276-7.
Ulcova-Gallova Z, Fialova P, Krauz V. (1994) Immunologic factors in human colostrum and milk. Casopis Lekaru Ceskych. 133:275-276.
Ungar BLP, Ward DJ, Fayer R, Quinn CA. (1990) Cessation of Cryptosporidium-associated diarrhea in an acquired immunodeficiency syndrome patient after treatment with hyperimmune bovine colostrum. Gastroenterology. 98:486-489.
Veselsky L, Cechova D, Jonakova V. (1978) Secretion and Immunochemical Properties of the Trypsin Inhibitor from Bovine Colostrum. Hoppe-Seyler's Z. Physiol. Chem. 359:873-878.
Waldman RH, Stone J, Lazzell V, et al. (1983) Oral route as method for immunizing against mucosal pathogens. Ann N Y Acad Sci. Jun 30;409:510.
Walker M. (1999) Bovine colostrum offers broad-spectrum benefits for wide-ranging ailments. Medical Journalist Report of Innovative Biologics: Townsend Letters for Doctors and Patients. 74-80.
Walker M. (1997) Homeostatic soil organisms support immune system functions from the ground up. Townsend Letters for Doctor and Patients.
Walker m. (1995) Infectious bugs are back but there's a remedy. Townsend Letters for Doctors and Patients.
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Allergies | Alzsheimers | Anti-Aging | Asthma | Anti-Inflammatory | Anti-Oxidant Properties | Athletic Performance |
Bacterial Infections | Cancer | Cytokines |
Diabetes |
General Information | Growth Factors | Heart Disease | Immune Factors |
Immune System | Infant Health | Intestinal Permeability | Lactoferrin
|
Leaky Gut Syndrome | Other | Other auto-immune disorders | Multiple Schlerosis (Auto-Immune Condition) |
Rheumatoid Arthritis | Sjogren's Syndrome | Skin Health | Supplement for Human Use|
HIV/AIDS | Viral Infections (Acute) | Wound Healing
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